Customer Profile Essay

Customer Profile 1. What is the approximate age range for people in this demographic group? -Someone born in Generation X ranges from 37-47 years old. 2. What are typical characteristics of people in this age group? -Gen X is often characterized by high levels of skepticism, â€Å"what’s in it for me† attitudes and a reputation for some of the worst music to ever gain popularity. 3. What are the interests of this age group? -Those born in Generation X are very family-oriented people that strive to not make their families like that of their parents but are also the first real charity driven generation. 4. What is this group’s source of income? -The group’s source of income derives mostly from permanent full-time jobs. 5. What might be their greatest social and economic concerns? -People of this generation are the first to really question the rules of society. 6. What issues regarding products might be important to them? -People of Generation X generally go for cost-efficient solutions when searching for products. 7. Where would they do the majority of their shopping? -People of Generation shop at places such as Nike, Walmart, Target, Victoria’s Secret, Costco, and Men’s Warehouse. 8. What types of products are targeted specifically at this age group? -Vitamins, clothing, baby supplies, office supplies, and groceries are all targeted for people of this generation. 9. How does your selected product fit this customer profile? -My product is useful for people of Generation X because Spotify allows users to access millions of songs from any genre or time period. This is useful because Generation X spent the prime of their life in the 1980’2 and 1990’s where music was at its biggest. 10. Also plan where your ad will be placed-indicate a specific magazine in which your ad will be seen? -Our ads will be placed on family television stations as well as over the radio and in print format through various music and electronics stores. Our product will need to be shown in Rolling Stone Magazine due to its vast following nation-wide.

Brain Tumour Glioblastoma Multiforme Problem Health And Social Care Essay

Glioblastoma, which is besides known as spongioblastoma multiforme ( GBM ) is the most common signifier of malignant encephalon tumor of grownups. It is the highest class ( grade IV ) astrocytomas, tumours that start in glial cells in the encephalon [ 1,25-27,36 ] . Each twelvemonth, about five out of 100 000 people populating in United State are diagnosed with this disease [ 28,29 ] . GBM normally affects people who older than 50 old ages old although the disease can happen in patients from all age group [ 2,25,28 ] . Patients suffer ictus, concern, ocular perturbation and sometimes personality alterations which can do great emotional hurt [ 25,30,31 ] . The average endurance of GBM patients is hapless, with about 12 to 14 months [ 7 ] . At this minute, the exact causes of GBM still remain vague to the scientists.Figure 1 GBM tumor is normally found in frontal and temporal lobe.Beginning: hypertext transfer protocol: //ebsco.smartimagebase.com/brain-tumor/view-item? ItemID=4027Accum ulative Word Count: 131Possible TreatmentsSurgerySurgery is normally the initial measure to handle GBM by taking every bit much tumor as possible. It is non healing but aims to cut down the tumor ‘s size every bit much as possible so that other therapies right after the surgery can be more effectual. Furthermore, surgical resection Acts of the Apostless to alleviate hydrops by debulking tumor every bit good as being a alleviative intervention for neurologic symptoms such as ictus activity [ 7 ] . The surgery includes standard surgical process craniotomy which removes a subdivision of skull to expose the encephalon underneath in order to unclutter the tumor. Besides, patients may choose to undergo optical maser microsurgery or supersonic aspiration to hold their tumors removed.2134Figure 2 Craniotomy hypertext transfer protocol: //ebsco.smartimagebase.com/surgical-craniotomy/view-item? ItemID=40345 Accumulative Word Count: 242Radiation TherapyNormally, radiation therapy ( RT ) is administered instantly after surgery. It works chiefly by damaging the Deoxyribonucleic acid of tumor cells, killing any residuary tumor cells after surgical remotion of the tumour [ 3-6,32 ] . A research has shown that the average endurance clip has increased from 17 hebdomads ( treated with conventional attention ) to 37.5 hebdomads when the GBM patients were treated with RT entirely while combination of BNCU ( carmustine ) and RT produced a 40.5 hebdomad average endurance [ 11 ] . Table 1 Randomized surveies of post-operative radiation compared with no radiation therapy in malignant gliomaa [ 23 ]Study [ Ref. ]Study groupRadiation dose Gy/ no. of fractionNo. of patients randomized ( analyzed )Median endurance ( hebdomads )Overall endurance P valueShapiro et al. , 1976 [ 62 ] Connecticut RT + CT–60 16 ( 16 ) 17 ( 17 ) 30 44.5 NR Not important Andersen, 1978 [ 1 ] Surgery entirely RT–45/25 57 ( 57 ) 51 ( 51 ) 15b 23b †¹0.005 Survival at 6 months Walker et al. , 1978 [ 78 ] vitamin D Surgery entirely RT–50-60/25-35 42 ( 31 ) 93 ( 68 ) 14c 36c 0.001 Walker et al. , 1980 [ 79 ] vitamin D Connecticut RT–60/30-35 111 ( 111 ) 118 ( 118 ) 31 37 0.003 Kristiansen et al. , 1981 [ 36 ] vitamin D Surgery entirely RT + / – Connecticut–45/25 38 ( 38 ) 80 ( 80 ) 23 47 NR Significant Sandberg-Wollheim et al. , 1991 [ 60 ] Connecticut RT + CT–58/27 87 ( 87 ) 84 ( 84 ) 42 62 0.028 a CT, chemotherapy ; NR, non reported ; RT, radiation therapy. B Calculated from survival curve. 500 Multi-arm survey that included a radiation plus chemotherapy arm. For both surveies by Walker et al. , merely information from the radiation entirely arm are shown in Table 2. Kristiansen et Al. reported combined informations from the radiation entirely arm and the radiation plus chemotherapy arm. In each of these surveies, there was a important survival benefit favouring radiation plus chemotherapy compared with no radiation therapy but no important difference in endurance between radiation entirely and radiation plus chemotherapy ( informations non shown ) . degree Celsiuss Merely consequences for the evaluable patients were reported ( 31 patients in the surgery entirely arm and 68 patients in the RT arm ) . Accumulative Word Count: 329 RT is normally administered through external beam radiation but internal radiation called Brachytherapy is besides possible. Each manner differs in how the radiation beginnings are delivered to the tumour [ 4-6,32 ] . Using IMRT ( Intensity-Modulated Radiation Therapy ) , a machine such as additive gas pedal delivers precise high-energy radiation doses ( eg: X raies ) to the tumor accurately and kills the affected cells [ 6,33 ] . Most patients will have the intervention for five to seven hebdomads [ 6,32,34 ] . Typically, around 6000 to 6500 units of radiation are delivered over seven hebdomads [ 6 ] . In contrast, brachytherapy topographic point the radiation beginnings every bit near as possible to the targeted cells in shorter clip comparison to external radiation. It consists of radioactive implants in the signifier of catheters or seeds which has impermanent radioactive beginnings in the tumor [ 8 ] . Figure 3 Brachythrapy hypertext transfer protocol: //ebsco.smartimagebase.com/brachytherapy/view-item? ItemID=24923 Besides, stereotactic radiosurgery, a noninvasive method of presenting an intense and focused dosage of radiation to a little country can be used for GBM excessively. Treatment dose is individualized but the typical dosage is about 2500 units of radiation per intervention [ 6 ] . Other signifiers of radiation intervention such as installing of inflatable balloon incorporating liquid radiation or interpolation of monoclonal antibodies tagged with radioactive substances may be used [ 8 ] . Accumulative Word Count: 519ChemotherapyChemotherapy may be given after surgical resection and radiation. In this therapy, chemotherapeutic drugs play an of import function in impacting retroflexing cells by damaging the Deoxyribonucleic acid of these cells. The most normally used drugs are carmustine ( BNCU ) , lomustine ( CCNU ) , temozolomide ( Temodar ) and procarbazine. They are classified as alkylating agents which are DNA-damaging drugs. These drugs alkylate the Deoxyribonucleic acid in the tumor cells, doing the dual strands to be cross-linked to each other in an inappropriate manner. This thereby, blocks DNA reproduction and bit by bit leads to cell decease [ 4,5,8 ] . Soon, Gliadel Wafer – a biodegradable wafer soaked with BNCU is prevailing among the interventions. This is done by engrafting wafers in the pit after surgical remotion of the tumor. The wafers so easy let go of high concentrations of BCNU straight into the tumour country over a period of 2-3 hebdomads. Gliadel does non supply a remedy for GBM but is believed to be capable of protracting endurance. Apart from that, temozolomide is more frequently administered orally on monthly rhythm for 6-12 months after surgery and radiation as a care therapy [ 6,8,28,29 ] . Traditional chemotherapy drugs can be effectual, but most of them do non separate between healthy and tumour cells, thereby forestalling the disposal of high doses to kill the unnatural cells. What is more, their generalised toxicity can do terrible side effects. Targeted therapy drugs like Avastin ( bevacizumab ) are more precise than some chemotherapy drugs and tend to hold fewer side effects. It has been approved by FDA in 2009 as a new biologic drug to handle GBM. Avastin acts chiefly as an angiogenesis inhibitors by decelerating the growing of new blood vass environing the tumor. It selectively blocks VEGF to suppress the activation of VEGF receptors tyrosine kinases VEGFR1 and VEGFR2 [ 13-15 ] . There are some surveies to turn out that approximately 20-30 % patients with GBM do react to the drugs [ 27 ] . Accumulative Word Count: 823AGraph 1 Kaplan-Meier endurance curves for patients treated with steroids and ( A ) resective surgery merely, ( B ) resective surgery and radiation therapy and ( C ) resective surgery, radiation therapy and chemotherapy. [ 12 ]BacillusCAccumulative Word Count: 848Social and Economic DeductionsThe trouble to digest with the side effects of the medicines such as sleepiness and hair loss may do GBM patients to experience down and hurt. They may be easy frustrated by concerns they suffer often or experience suffering and hopeless after the diagnosing [ 34 ] . This could take to serious societal impact and would worry the people around them. Furthermore, most of the patients find it hard to return to work due to decrease in productiveness. A study has shown that with 91 % patients were employed before diagnosing, merely 33 % of them continue working after interventions. While health professionals who were still working experience employment alterations such as taking leave of absence to be with their loved 1s for interventions or taking on extra paid work might experience stressed and have to fight difficult to get by with the tough life [ 9 ] . In order to run a normal life, patients require undergo a plentifulness of interventions including hospitalization after surgery which would do great fiscal load. It is estimated that cost of GBM interventions ranged from ˆ10 893 to ˆ125 275 [ 22 ] . Trouble of obtaining insurance makes the status even worse. Drugs that are necessary for GBM interventions are expensive and are normally administered over long period of clip. All this becomes a beginning of depression which affects non merely the patients but their households and friends [ 9 ] . The return of GBM after conventional therapy is inevitable. This so creates unstoppable medical crisis every bit good as fiscal hurt to the patients and their households. Accumulative Word Count: 1084Benefits and HazardsI believe a combination of surgery, radiation therapy and chemotherapy is the most effectual intervention for GBM presently. In malice of its forecast has remained hapless for the last few decennaries, patients do acquire better after adhering to this standard therapy. Although GBM can non be cured, the patients had have their survival clip prolonged, acquiring a opportunity to pass their last few months with their loved 1s in a meaningful manner [ 34 ] . Nevertheless, the interventions do enforce distressing side effects to human wellness. Despite killing tumour cells, alkylating agents used are considered toxic, ensuing in suppression or lowering of blood counts. They have been associated with important sickness, hair loss, weariness and sterility [ 5 ] . High doses of BNCU may take to damage and marking of the lungs while procarbazine can do raging concern, purging and numbness. Hence, doses of drugs administered have to be carefull y monitored by doctor to avoid taking to unwanted effects. Recently invented drugs temozolomide, has comparatively mild side effects but they are still inevitable [ 6 ] . Meanwhile, hazard of developing acute leukaemia old ages subsequently is increased when patients are exposed to alkylating agents [ 5 ] . Avastin, a freshly developed drug, provides a more effectual therapy for GBM. However, it potentially creates fatal toxicity, doing the late closed surgical lesion interruptions down. Some claim that the development of toxicity by avastin may shorten endurance in some patients when it is added to radiotherapy and temozolomide. Thus, researches on the effectivity and safety of use of avastin should be carried on continually until desirable consequences are obtained [ 20 ] . In add-on, the return of the tumor is ineluctable, with the average endurance rate of patients who relapse runing from 3-6 months despite aggressive intervention [ 10 ] . Patients may develop the feeling that the medicines are useless or may give up because of the intolerable side effects and the unstoppable backsliding of disease. This will take to non-adherence to therapy and increase the hazard of mortality. However, in my sentiment, the multimodal treatments I discuss above are still considered the best solution for GBM as they outweigh the hazards by protracting the patients ‘ survival clip. Accumulative Word Count: 1432Alternate TreatmentsGene therapyAnother promising attack of handling GBM is cistron therapy. Herpes simplex virus thymidine kinase/ganciclovir ( HSV-tk/GCV ) has evolved as a cytotoxic cistron therapy. In this instance, recombinant adenoviral vectors are used to give favorable consequences. Adenoviral HSV-tk ( AdHSV-tk ) is able to assail the residuary dividing tumour cells while go forthing the non-dividing nerve cells unharmed. What ‘s more, it can destruct the malignant neoplastic disease cells through bystander- consequence [ 19 ] . HSV-tk first converts GCV to GCV-monophosphate [ 16,17 ] . Then, cellular kinases farther convert this merchandise to GCV-triphosphate which is a hapless substrate for uninterrupted DNA elongation due to the lacking of 3 ‘ hydroxyl group that is needed to organize phosphodiester bond in chain-elongation-reaction. Ultimately, nonfunctional Deoxyribonucleic acid fragments are formed, triping programmed cell death in malignant neoplastic disease cells [ 18 ] . Nowadays, AdHSV-tk /GCV is going preferred comparisons to conventional radiation therapy and chemotherapy due to its fewer inauspicious effects. Figure 4 The rule of HSV-tk/GCV cistron therapy. hypertext transfer protocol: //www.gtmb.org/VOL4A/GTMBVOL4AHTML/23_Adachi_files/image001.gif Accumulative Word Count: 1575 Table 2 Surveies by Sandmair et Al. and Immonen et Al. demo a singular protraction of endurance in patients treated with AdHSV-tk [ 19 ] . Patients Vector Phase Gene Transfer Method Adverse Effectss Survival ( Months ) Response

Beethovens Hair Research Paper Example | Topics and Well Written Essays - 1000 words

Beethovens Hair - Research Paper Example Along with these theories of Beethoven’s music composition style, number of theories are being put forward and even tested by the researchers on what exactly caused deafness in him. It was around 1800s, by the age of 26, when Beethoven began lose hearing in both his ears. Initially, he suffered from a serious form of ear disease called Tinnitus, because of which he mainly heard ‘ringing’ sound in his ears, thereby making it difficult for him to hear the music. Then, over time, mainly around early 1820s, his hearing loss became more intense, with Beethoven not able to even acknowledge the tumultuous applause, which he received from a huge crowd at a concert, as he was not facing the crowd and mainly because he was not able to hear it. (Colles and Grove). Although, he gave up conducting public concerts, he continued to compose and that resulted in many of his celebrated works. The exact cause of his deafness is unknown, but based on the study of old literature and importantly on the current researches being conducted by prestigious institutions, certain probable causes are being put forward. In addition, the recovery of Beethoven’s hair and advanced testing of it including Forensic testing have unlocked details about various facets of his life, particularly the physical as well as social factors, which could have contributed to his deafness. â€Å"Scientists tested a lock of Beethovens hair in hopes that, at last, the world would have explanation for the composers deafness.† (Martin and Nibley 30). Before this testing was done, various causes was attributed to his hearing loss and that included otosclerosis or abnormal growth of bone in his inner ear, typhus, syphilis and lead poisoning. Among these four causes, the first two were discounted earlier or could not be proved, with the later two being discussed through current researches. Otoscl erosis is a disease which happens when there is â€Å"new bone formation either in the area of

NO TOPIC JUST DISCUSSION QUESTIONS Dissertation Example | Topics and Well Written Essays - 250 words

NO TOPIC JUST DISCUSSION QUESTIONS - Dissertation Example It is one’s contention that the change was managed successfully paving the way for various suppliers and customers to take advantage of advanced communication, computer, and mobile services at increasing volume and decreasing costs. Despite the efficiency and success of contemporary organizations in the industry, future challenges come in terms of continued reliability and sustainability of the system as well as controls in costs of both telecommunications equipment and services. Discussion Question 2: The force field analysis is a viable tool to initiate changes at work through the identification and evaluation of both driving forces and forces of resistance. As indicated, through brainstorming, one is made to clearly itemize these forces and determine which force/s have greater intensities that could assist in the accomplishment of identified change goals.

The Microsoft Dominance Essay Example | Topics and Well Written Essays - 1000 words

The Microsoft Dominance - Essay Example The paper tries to analyse the economic position of Microsoft and understand why they have been able to retain themselves as a monopoly in the market. Let us start with the definition of monopoly and then analyse the same definition with respect to the share controlled by Microsoft in the market. â€Å"A situation in which a single company or group owns all or nearly all of the market for a given type of product or service. By definition, monopoly is characterized by an absence of competition, which often results in high prices and inferior products.† Monopoly Definition." Investopedia.com - Your Source For Investing Education Inferring from the above definition, a monopoly is a state of market where one company controls the market with a tight management in place and holding a dominant share where it can dictate the prices and the supply of the product to the market and therefore would exercise a position of power in the respective market. Microsoft enjoyed such dominance in the OS market for computers for two decades and still holds that position due to the free availability of its products in the market. â€Å"Microsoft accounts for 90-95% of microcomputer operating systems, and it is the de facto standard for computer applications. It is obvious that it is dominating the market. However, one could argue that its market power is gained from the consumer choices†¦its legitimacy rests upon consumers who willingly, and in a market with alternative resources and options, chose to buy Microsoft products.† InfoTech & Public Policy  » Blog Archive  » Is Microsoft a â€Å"monopoly† Based on Standard Economic Theory?" The economic theory behind the dominance of Microsoft has been monopolizing the market and creating products which the competitors failed to innovate in. Microsoft was able to take the Windows to a level where there was no competition at all from the rest of the players in the market. Let is have a look at the OS market to understand why Microsoft was so successful in monopolizing the market for such a long time. At the time when Windows was launched, there were only two players in the market for OS. One was the Macintosh designed by Apple, and the other was windows designed by Microsoft. The precarious thing about Apple was that they only created their OS for their own machines and did not outsource the product to other manufacturers waiting in line to produce the Macintosh. Since Apple did not sell their Macintosh OS to third parties, the manufacturers were left with only one option, and that was to buy the OS from Microsoft, the Windows based application. Since Macintosh was more expensive than Windows and did not give an opportunity to oither manufacturers in the market to use their OS, the Windows grew in popularity. The OS was much more cheaper to use and to apply on machines, and since was an open software there were more applications designed for it than they were for the Macintosh. â€Å"eco nomists maintain that a monopoly does not exist simply because there is only one provider of a good or service. For example, in the Microsoft case, the Windows operating system is enormously popular, but the potential for a competing firm to provide a similar product exists. In fact, Macintosh is a small but important competitor in the computer and operating system market. Linux has also emerged in recent months as a viable alternative to Microsoft Windows† South-Western: Is Microsoft A Monopoly?" Web. 27 Nov. 2011. Whether the Monopoly is in the Public Interest: There are two sides to the argument whether the monopoly has been in the public interest or not. The paper address both the points of contention and then understand why one arguments

Protecting the Interests of the Employees Assignment

Protecting the Interests of the Employees - Assignment Example The main aim why the WARN act was initiated to offer advance notices was to allow the employee and their families sufficient time to adjust to the prospective job termination. This also allows them to seek other employment opportunities as well acquisition of new skills that will make them more competitive in their new job prospects. There are a number of employees who are not covered by the WARN Act hence they are not subject to advance notice by their employers. Such include workers who are taking part in strike actions as well as those who are subject to labor disputes. Business partners, contract employees, and consultants who are charged with the responsibility for some period by an organization are not entitled to notification from their employers (Ford, et. al, 2000). The federal, local government and state employees are not subject to the Act as they are deemed to be protected by the government under other labor laws. Those employed on the temporary basis and those who have no direct control of the undertakings of the companies that they are working for are left out of the Warn Act. One of the factors that trigger the issuance of advance notice is the closure of a plant. An employer who is covered by the Act must issue the notice in circumstances where an employment site is to be shut down which is likely to lead to loss of employment. The only exemption to those who are to receive notice are the employees who have only worked for a period of six months in the last one year and those who work for the employer for an average of 20 hours per week. Another trigger is during mass layoffs in which an employer under the Act must issue advance notice where loss of employment is likely to take place (the United States, 1993). The general requirements for the notice include the fact that all must be made in writing but any method of delivery s acceptable. The notice has to be very specific and it must be given conditionally upon the occurrence or the non-occurrence of a given event. The WARN Act is thus a clear provision of the law that seeks to protect the interest of t he American workers. This Act has seen its application in all the states in a bid to safeguard the interest of the employees.        

System Implementation At Red and Hot Chinese Restaurant Assignment

System Implementation At Red and Hot Chinese Restaurant - Assignment Example HACCP is in line with the ISO 9000 standards in terms of ensuring safe restaurant kitchen operations. It is based on the seven principles recommended by the US National Advisory Committee on Microbiological Criteria for Foods (NACMCF). It is defined as a system of controls and documentation designed to minimize the potential for food-borne illness due to pathogens or the physical or chemical combination. (Baraban and Durocher, p. 134) It addresses all biological, chemical and physical hazards and how to identify and control/prevent them. Food safety has become an important public policy issue because of concerns about food-borne illnesses and how consumers have increasingly sought ways to lead healthful lifestyles. (Engle and Quagrainie 2006, p. 151) As a result, authorities are increasingly requiring for food establishments and food handlers to have control on sanitation procedures. Some countries are even formulating laws that are related to food safety and the HACCP system. The entire HACCP processes look and appear very technical and complicated, but the truth is that it is an extremely systematic way of ensuring that food is produced in a kitchen is safe. Based on initial research, the HACCP system is a recognized as a worldwide standard in food safety, adopted by various food and hospitality establishments such as hotels, restaurant, ships, and so forth. While there is no formal HACCP system in place at Red and Hot Chinese Restaurant, this does not mean that there is no food safety strategy in place. I found this out, among other important facts about the restaurant, after I conducted a series of interviews with the Kitchen manager, several cooks, stewards and food servers. I have asked a set of questions which determined the staff’s knowledge and actual experience with the HACCP model and how it works.